Reason Behind Suffering From Restless Leg Syndrome

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A team of scientists from the Europe, US and Canada have identified two genetic mutations first time in the world, which usually cause restless leg syndrome or RLS. This discovery is enough being able to origin the one most common neurological diseases which can even pave the new way for drugs.

More than 10 percent of the adults have to experience RLS at some stage in their life, which means suffering from the unpleasant sensations in their legs. The only way to prevent it is walking, moving and jogging.

In order to improve diagnostic and the treatment of the patients, the institutes like Human Genetics, Technische Universität Munich and Helmholtz Zentrum Munich have been researching on the origin of the Restless Leg Syndrome for many years.

To justify the internal fact of the study, Professor Juliane Winkelmann, the leader of this study, has included more than 4,867 Restless Leg Syndrome patients and 7,280 control patients.

Through out, the entire survey those researchers all around the world have analyzed some genetic sequence variants or SNPs which generally disturbs the entire genome. Aside from that they have discovered two genetic reasons also which generally play a key role in the area of development of RLS.

Though, one of these regions is situated with in the area of gene that generally involve with regulating brain activity. It is globally known as TOX3. Moreover, it has also broadcasted throughout the entire study that too much increment of TOX3 protein means get too much protection from neuronal cell or death cells. But they have not cleared anything about the internal relation between TOX3 and RLS.

Moreover, these findings are quite being able to enable further investigation into an underlying mechanism, which can be developed in these lights of new study.

The above thing is published in the open-access journal PLoS Genetics this week.